The DNA Damage Response Pathway Contributes to the Stability of Chromosome III Derivatives Lacking Efficient Replicators

In eukaryotic chromosomes, DNA replication initiates at multiple origins. Large inter-origin gaps arise when several adjacent origins fail to fire. Little is known about how cells cope with this situation. We created a derivative of Saccharomyces cerevisiae chromosome III lacking all efficient origi...

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Autores principales: Theis, James F., Irene, Carmela, Dershowitz, Ann, Brost, Renee L., Tobin, Michael L., di Sanzo, Fabiana M., Wang, Jian-Ying, Boone, Charles, Newlon, Carol S.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2996327/
https://ncbi.nlm.nih.gov/pubmed/21151954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1001227
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