Modeling Conformational Ensembles of Slow Functional Motions in Pin1-WW

Protein-protein interactions are often mediated by flexible loops that experience conformational dynamics on the microsecond to millisecond time scales. NMR relaxation studies can map these dynamics. However, defining the network of inter-converting conformers that underlie the relaxation data remai...

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Main Authors: Morcos, Faruck, Chatterjee, Santanu, McClendon, Christopher L., Brenner, Paul R., López-Rendón, Roberto, Zintsmaster, John, Ercsey-Ravasz, Maria, Sweet, Christopher R., Jacobson, Matthew P., Peng, Jeffrey W., Izaguirre, Jesús A.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2010
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2996313/
https://ncbi.nlm.nih.gov/pubmed/21152000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1001015
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