Dual inhibition of sodium-mediated proton and calcium efflux triggers non-apoptotic cell death in malignant gliomas

Malignant glioma cells maintain an elevated intracellular pH (pH(i)) within hypoxic-ischemic tumor microenvironments through persistent activation of sodium-proton transport (McLean et al., 2000). Amiloride has been reported to selectively kill human malignant glioma cell lines but not primary astro...

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Detalhes bibliográficos
Main Authors: Harley, William, Floyd, Candace, Dunn, Tamara, Zhang, Xiao-Dong, Chen, Tsung-Yu, Hegde, Manu, Palandoken, Hasan, Nantz, Michael H., Leon, Leonardo, Carraway, K L, Lyeth, Bruce, Gorin, Fredric A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2996276/
https://ncbi.nlm.nih.gov/pubmed/20869350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2010.09.059
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