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Identification of a gene that regulates expression of M protein, the major virulence determinant of group A streptococci.
By using Tn916 insertional mutagenesis, we have identified mry (M protein RNA yield), a gene required for high-level expression of the M protein, an essential virulence determinant of the group A streptococcus. The mry::Tn916 mutation causes a reduction by a factor of approximately equal to 50 in th...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1987
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC299609/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2446327/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.23.8677 |
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