Hepatocyte apoptotic bodies encasing nonstructural HCV proteins amplify hepatic stellate cell activation: implications for chronic hepatitis C

Chronic hepatitis C infection leads to increased hepatocyte apoptosis. Because engulfment of apoptotic bodies (ABs) by hepatic stellate cells (HSC) is profibrogenic, we compared the effects of ABs derived from HCV-negative vs. HCV-infected (Con1+) Huh7 hepatoblastoma cells on fibrogenic and activati...

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Main Authors: Gieseler, Robert K., Marquitan, Guido, Schlattjan, Martin, Sowa, Jan-Peter, Bechmann, Lars P., Timm, Jörg, Roggendorf, Michael, Gerken, Guido, Friedman, Scott L., Canbay, Ali
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2995835/
https://ncbi.nlm.nih.gov/pubmed/20723040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2893.2010.01362.x
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