Molecular cloning and sequence analysis of the Plasmodium falciparum dihydrofolate reductase-thymidylate synthase gene.

Genomic DNA clones that coded for the bifunctional dihydrofolate reductase (DHFR) and thymidylate synthase (TS) (DHFR-TS) activities from a pyrimethamine-sensitive strain of Plasmodium falciparum were isolated and sequenced. The deduced DHFR-TS protein contained 608 amino acids (71,682 Da). The codi...

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Main Authors: Bzik, D J, Li, W B, Horii, T, Inselburg, J
格式: Artigo
語言:Inglês
出版: 1987
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC299542/
https://ncbi.nlm.nih.gov/pubmed/2825189
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