Molecular cloning and sequence analysis of the Plasmodium falciparum dihydrofolate reductase-thymidylate synthase gene.

Genomic DNA clones that coded for the bifunctional dihydrofolate reductase (DHFR) and thymidylate synthase (TS) (DHFR-TS) activities from a pyrimethamine-sensitive strain of Plasmodium falciparum were isolated and sequenced. The deduced DHFR-TS protein contained 608 amino acids (71,682 Da). The codi...

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Vydáno v:	Proc Natl Acad Sci U S A
Hlavní autoři:	Bzik, D J, Li, W B, Horii, T, Inselburg, J
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	National Academy of Sciences 1987
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC299542/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2825189/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.23.8360
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