NBS1 cooperates with homologous recombination to counteract chromosome breakage during replication

Nijmegen breakage syndrome (NBS) is characterized by genome instability and cancer predisposition. NBS patients contain a mutation in the NBS1 gene, which encodes the NBS1 component of the DNA double-strand break (DSB) response complex MRE11/RAD50/NBS1. To investigate the NBS phenotype in more detai...

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Main Authors: Brugmans, Linda, Verkaik, Nicole S., Kunen, Maurice, van Drunen, Ellen, Williams, Bret R., Petrini, John H.J., Kanaar, Roland, Essers, Jeroen, van Gent, Dik C.
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2995292/
https://ncbi.nlm.nih.gov/pubmed/19782649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2009.09.002
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