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Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

PINK1 is a mitochondrial kinase mutated in some familial cases of Parkinson’s disease. It has been found to work in the same pathway as the E3 ligase Parkin in the maintenance of flight muscles and dopaminergic neurons in Drosophila melanogaster and to recruit cytosolic Parkin to mitochondria to med...

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Bibliografske podrobnosti
Main Authors: Jin, Seok Min, Lazarou, Michael, Wang, Chunxin, Kane, Lesley A., Narendra, Derek P., Youle, Richard J.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2995166/
https://ncbi.nlm.nih.gov/pubmed/21115803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201008084
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