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Protein kinase A–induced myofilament desensitization to Ca(2+) as a result of phosphorylation of cardiac myosin–binding protein C
In skinned myocardium, cyclic AMP–dependent protein kinase A (PKA)-catalyzed phosphorylation of cardiac myosin–binding protein C (cMyBP-C) and cardiac troponin I (cTnI) is associated with a reduction in the Ca(2+) responsiveness of myofilaments and an acceleration in the kinetics of cross-bridge cyc...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The Rockefeller University Press
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2995154/ https://ncbi.nlm.nih.gov/pubmed/21115695 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201010448 |
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