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Chemical discrimination between dC and (5Me)dC via their hydroxylamine adducts
The presence of the methylated nucleobase (5Me)dC in CpG islands is a key factor that determines gene silencing. False methylation patterns are responsible for deteriorated cellular development and are a hallmark of many cancers. Today genes can be sequenced for the content of (5Me)dC only with the...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2995083/ https://ncbi.nlm.nih.gov/pubmed/20813757 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq724 |
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