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Genomic RNAs of influenza viruses are held in a circular conformation in virions and in infected cells by a terminal panhandle.

The viral RNA segments in influenza virions were shown to be circular in conformation by using psoralen crosslinking methods. Electron microscopy of purified RNA following treatment of virus with the psoralen reagent 4'-aminomethyltrioxsalen (AMT) revealed circles with lengths corresponding to the i...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Hsu, M T, Parvin, J D, Gupta, S, Krystal, M, Palese, P
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1987
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC299494/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2446318/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.22.8140
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