12(R)-hydroxyicosatetraenoic acid: a cytochrome-P450-dependent arachidonate metabolite that inhibits Na+,K+-ATPase in the cornea.
When corneal microsomes were incubated with arachidonic acid in the presence of an NADPH-generating system, four polar metabolites (compounds A-D) were formed. Synthesis of these metabolites could be inhibited by carbon monoxide, SKF 525A, and anti-cytochrome c reductase antibodies. One of the metab...
সংরক্ষণ করুন:
| প্রকাশিত: | Proc Natl Acad Sci U S A |
|---|---|
| প্রধান লেখক: | , , , , , |
| বিন্যাস: | Artigo |
| ভাষা: | Inglês |
| প্রকাশিত: |
National Academy of Sciences
1987
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| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC299491/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2825178/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.22.8125 |
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