A non-BRICHOS surfactant protein c mutation disrupts epithelial cell function and intercellular signaling

BACKGROUND: Heterozygous mutations of SFTPC, the gene encoding surfactant protein C (SP-C), cause sporadic and familial interstitial lung disease (ILD) in children and adults. The most frequent SFTPC mutation in ILD patients leads to a threonine for isoleucine substitution at position 73 (I73T) of t...

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Autors principals: Woischnik, Markus, Sparr, Christiane, Kern, Sunčana, Thurm, Tobias, Hector, Andreas, Hartl, Dominik, Liebisch, Gerhard, Mulugeta, Surafel, Beers, Michael F, Schmitz, Gerd, Griese, Matthias
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2010
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2994813/
https://ncbi.nlm.nih.gov/pubmed/21092132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2121-11-88
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