The surfactant protein C mutation A116D alters cellular processing, stress tolerance, surfactant lipid composition, and immune cell activation

BACKGROUND: Surfactant protein C (SP-C) is important for the function of pulmonary surfactant. Heterozygous mutations in SFTPC, the gene encoding SP-C, cause sporadic and familial interstitial lung disease (ILD) in children and adults. Mutations mapping to the BRICHOS domain located within the SP-C...

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Main Authors: Zarbock, Ralf, Woischnik, Markus, Sparr, Christiane, Thurm, Tobias, Kern, Sunčana, Kaltenborn, Eva, Hector, Andreas, Hartl, Dominik, Liebisch, Gerhard, Schmitz, Gerd, Griese, Matthias
格式: Artigo
語言:Inglês
出版: BioMed Central 2012
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3376036/
https://ncbi.nlm.nih.gov/pubmed/22458263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2466-12-15
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