Statins Inhibit Angiotensin II/Smad Pathway and Related Vascular Fibrosis, by a TGF-β-Independent Process

We have recently described that in an experimental model of atherosclerosis and in vascular smooth muscle cells (VSMCs) statins increased the activation of the Smad pathway by transforming growth factor-β (TGF-β), leading to an increase in TGF-β-dependent matrix accumulation and plaque stabilization...

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Detalhes bibliográficos
Main Authors: Rodrigues Díez, Raúl, Rodrigues-Díez, Raquel, Lavoz, Carolina, Rayego-Mateos, Sandra, Civantos, Esther, Rodríguez-Vita, Juan, Mezzano, Sergio, Ortiz, Alberto, Egido, Jesús, Ruiz-Ortega, Marta
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2994748/
https://ncbi.nlm.nih.gov/pubmed/21152444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0014145
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