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Structural alterations of DNA ligase I in Bloom syndrome.
Cell lines derived from seven patients with Bloom syndrome all contain a DNA ligase I with unusual properties. Six lines were shown to have a reduced level of this enzyme activity and the residual enzyme was anomalously heat-labile. The seventh line contained a dimeric rather than monomeric form of...
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| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
1987
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC299467/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3479778/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.22.8016 |
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