A phase I dose-escalation study to evaluate safety and tolerability of sorafenib combined with sirolimus in patients with advanced solid cancer

BACKGROUND: The combination of sorafenib (vascular endothelial growth factor receptor 2 inhibitor) and sirolimus (mammalian target of rapamycin inhibitor) might work synergistically. METHODS: A phase I dose-escalation study with sorafenib twice a day (b.i.d.) and sirolimus once daily (q.d.) was perf...

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Autors principals: Desar, I M E, Timmer-Bonte, J N H, Burger, D M, van der Graaf, W T A, van Herpen, C M L
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2010
Matèries:
Clinical Study
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2994217/
https://ncbi.nlm.nih.gov/pubmed/21045832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605777
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