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Bacteriophage T4 regA protein binds to mRNAs and prevents translation initiation.

The bacteriophage T4 regA protein is a translational repressor of a subset of phage mRNAs. We show here that purified regA protein binds specifically to target mRNAs near the initiating AUG and occludes binding of ribosomes. Translational repression by regA protein diminishes expression of many gene...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Winter, R B, Morrissey, L, Gauss, P, Gold, L, Hsu, T, Karam, J
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1987
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC299406/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3120177/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.22.7822
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