Break-induced ATR and Ddb1–Cul4(Cdt2) ubiquitin ligase-dependent nucleotide synthesis promotes homologous recombination repair in fission yeast

Nucleotide synthesis is a universal response to DNA damage, but how this response facilitates DNA repair and cell survival is unclear. Here we establish a role for DNA damage-induced nucleotide synthesis in homologous recombination (HR) repair in fission yeast. Using a genetic screen, we found the D...

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Detalhes bibliográficos
Main Authors: Moss, Jennifer, Tinline-Purvis, Helen, Walker, Carol A., Folkes, Lisa K., Stratford, Michael R., Hayles, Jacqueline, Hoe, Kwang-Lae, Kim, Dong-Uk, Park, Han-Oh, Kearsey, Stephen E., Fleck, Oliver, Holmberg, Christian, Nielsen, Olaf, Humphrey, Timothy C.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2010
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2994043/
https://ncbi.nlm.nih.gov/pubmed/21123655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1970810
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