Transactivation of Schizosaccharomyces pombe cdt2(+) stimulates a Pcu4–Ddb1–CSN ubiquitin ligase

Cullin-4 forms a scaffold for multiple ubiquitin ligases. In Schizosaccharomyces pombe, the Cullin-4 homologue (Pcu4) physically associates with Ddb1 and the COP9 signalosome (CSN). One target of this complex is Spd1. Spd1 regulates ribonucleotide reductase (RNR) activity. Spd1 degradation during S...

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Main Authors: Liu, Cong, Poitelea, Marius, Watson, Adam, Yoshida, Shu-hei, Shimoda, Chikashi, Holmberg, Christian, Nielsen, Olaf, Carr, Antony M
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2005
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1283953/
https://ncbi.nlm.nih.gov/pubmed/16252005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600854
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