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Synaptic Protection in the Brain of Wld(S) Mice Occurs Independently of Age but Is Sensitive to Gene-Dose

BACKGROUND: Disruption of synaptic connectivity is a significant early event in many neurodegenerative conditions affecting the aging CNS, including Alzheimer's disease and Parkinson's disease. Therapeutic approaches that protect synapses from degeneration in the aging brain offer the pote...

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Autors principals: Wright, Ann K., Wishart, Thomas M., Ingham, Cali A., Gillingwater, Thomas H.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993971/
https://ncbi.nlm.nih.gov/pubmed/21124744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015108
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