Carcinogen-induced mdr overexpression is associated with xenobiotic resistance in rat preneoplastic liver nodules and hepatocellular carcinomas.

We have previously reported the isolation of a human breast cancer cell line resistant to doxorubicin (adriamycin; AdrR MCF-7 cells) that has also developed the phenotype of multidrug resistance (MDR). MDR in this cell line is associated with increased expression of mdr (P glycoprotein) gene sequenc...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Fairchild, C R, Ivy, S P, Rushmore, T, Lee, G, Koo, P, Goldsmith, M E, Myers, C E, Farber, E, Cowan, K H
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 1987
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC299368/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2890168/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.21.7701
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