Transplantation of mouse HSCs genetically modified to express a CD4-restricted TCR results in long-term immunity that destroys tumors and initiates spontaneous autoimmunity

The development of effective cancer immunotherapies has been consistently hampered by several factors, including an inability to instigate long-term effective functional antitumor immunity. This is particularly true for immunotherapies that focus on the adoptive transfer of activated or genetically...

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Detalhes bibliográficos
Main Authors: Ha, Sung P., Klemen, Nicholas D., Kinnebrew, Garrett H., Brandmaier, Andrew G., Marsh, Jon, Hangoc, Giao, Palmer, Douglas C., Restifo, Nicholas P., Cornetta, Kenneth, Broxmeyer, Hal E., Touloukian, Christopher E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993591/
https://ncbi.nlm.nih.gov/pubmed/21084750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43274
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