Antibody-enhanced thrombolysis: targeting of tissue plasminogen activator in vivo.

Tissue plasminogen activator (tPA) was modified by the unidirectional crosslinking reagent N-succinimidyl 3-(2-pyridyldithio)propionate and coupled to iminothiolane-modified anti-fibrin antibody 59D8 by the formation of disulfide bonds at neutral pH. Purification by two affinity-chromatography steps...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Runge, M S, Bode, C, Matsueda, G R, Haber, E
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1987
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC299359/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3118374/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.21.7659
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