Antibody-enhanced thrombolysis: targeting of tissue plasminogen activator in vivo.
Tissue plasminogen activator (tPA) was modified by the unidirectional crosslinking reagent N-succinimidyl 3-(2-pyridyldithio)propionate and coupled to iminothiolane-modified anti-fibrin antibody 59D8 by the formation of disulfide bonds at neutral pH. Purification by two affinity-chromatography steps...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1987
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC299359/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3118374/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.21.7659 |
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