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Enigma negatively regulates p53 through MDM2 and promotes tumor cell survival in mice
The human E3 ubiquitin ligase murine double minute 2 (MDM2) targets the tumor suppressor p53 for ubiquitination and degradation but also promotes its own ubiquitination and subsequent degradation. As the balance between MDM2 and p53 levels plays a crucial role in regulating cell proliferation and ap...
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| Hlavní autoři: | , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Clinical Investigation
2010
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2993588/ https://ncbi.nlm.nih.gov/pubmed/21060154 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI42674 |
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