Insulin-induced hypoglycemia increases hepatic sensitivity to glucagon in dogs

In individuals with type 1 diabetes, hypoglycemia is a common consequence of overinsulinization. Under conditions of insulin-induced hypoglycemia, glucagon is the most important stimulus for hepatic glucose production. In contrast, during euglycemia, insulin potently inhibits glucagon’s effect on th...

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Autori principali: Rivera, Noelia, Ramnanan, Christopher J., An, Zhibo, Farmer, Tiffany, Smith, Marta, Farmer, Ben, Irimia, Jose M., Snead, Wanda, Lautz, Margaret, Roach, Peter J., Cherrington, Alan D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2010
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993579/
https://ncbi.nlm.nih.gov/pubmed/21084754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI40919
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