High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio

At present, there are few means to track symptomatic stages of CNS aging. Thus, although metabolic changes are implicated in mtDNA mutation-driven aging, the manifestations remain unclear. Here, we used normally aging and prematurely aging mtDNA mutator mice to establish a molecular link between mit...

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Detalhes bibliográficos
Main Authors: Ross, Jaime M., Öberg, Johanna, Brené, Stefan, Coppotelli, Giuseppe, Terzioglu, Mügen, Pernold, Karin, Goiny, Michel, Sitnikov, Rouslan, Kehr, Jan, Trifunovic, Aleksandra, Larsson, Nils-Göran, Hoffer, Barry J., Olson, Lars
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993405/
https://ncbi.nlm.nih.gov/pubmed/21041631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1008189107
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