Silencing the Expression of Ras Family GTPase Homologues Decreases Inflammation and Joint Destruction in Experimental Arthritis

Changes in the expression and activation status of Ras proteins are thought to contribute to the pathological phenotype of stromal fibroblast-like synoviocytes (FLS) in rheumatoid arthritis, a prototypical immune-mediated inflammatory disease. Broad inhibition of Ras and related proteins has shown p...

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Autors principals: de Launay, Daphne, Vreijling, Jeroen, Hartkamp, Linda M., Karpus, Olga N., Abreu, Joana R.F., van Maanen, Marjolein A., Sanders, Marjolein E., Grabiec, Aleksander M., Hamann, Jörg, Ørum, Henrik, Vervoordeldonk, Margriet J., Fluiter, Kees, Tak, Paul P., Reedquist, Kris A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2010
Matèries:
Regular Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993305/
https://ncbi.nlm.nih.gov/pubmed/20971740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.091053
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