The Ras guanine nucleotide exchange factor RasGRF1 promotes matrix metalloproteinase-3 production in rheumatoid arthritis synovial tissue

INTRODUCTION: Fibroblast-like synoviocytes (FLS) from rheumatoid arthritis (RA) patients share many similarities with transformed cancer cells, including spontaneous production of matrix metalloproteinases (MMPs). Altered or chronic activation of proto-oncogenic Ras family GTPases is thought to cont...

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Autori principali: Abreu, Joana RF, de Launay, Daphne, Sanders, Marjolein E, Grabiec, Aleksander M, Sande, Marleen G van de, Tak, Paul P, Reedquist, Kris A
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2009
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2745805/
https://ncbi.nlm.nih.gov/pubmed/19678938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar2785
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