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Bioactivation mechanism of the cytotoxic and nephrotoxic S-conjugate S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine.

The bioactivation of S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine (CTFC) was studied with purified bovine kidney cysteine conjugate beta-lyase and with N-dodecylpyridoxal bromide in cetyltrimethylammonium bromide micelles as a pyridoxal model system. The beta-lyase and the pyridoxal model system con...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Dekant, W, Lash, L H, Anders, M W
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1987
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC299312/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3478703/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.21.7443
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