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CTLA-4 Blockade following Relapse of Malignancy after Allogeneic Stem Cell Transplantation is Associated with T cell Activation but not Increased Levels of T Regulatory Cells

Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) is a key negative regulator of T cell activation and proliferation. Ipilimumab is a human monoclonal antibody that specifically blocks the binding of CTLA-4 to its ligand. To test the hypothesis that blockade of CTLA-4 by ipilimumab could augment...

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Hlavní autoři:	Zhou, Jiehua, Bashey, Asad, Zhong, Ruikun, Corringham, Sue, Messer, Karen, Pu, Minya, Ma, Wenxue, Soiffer, Robert, Mitrovich, Rachel C, Lowy, Israel, Ball, Edward D.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	2010
Témata:	Article
On-line přístup:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2992836/ https://ncbi.nlm.nih.gov/pubmed/20713164 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbmt.2010.08.005
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CTLA-4 Blockade following Relapse of Malignancy after Allogeneic Stem Cell Transplantation is Associated with T cell Activation but not Increased Levels of T Regulatory Cells

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