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CTLA-4 Blockade following Relapse of Malignancy after Allogeneic Stem Cell Transplantation is Associated with T cell Activation but not Increased Levels of T Regulatory Cells
Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) is a key negative regulator of T cell activation and proliferation. Ipilimumab is a human monoclonal antibody that specifically blocks the binding of CTLA-4 to its ligand. To test the hypothesis that blockade of CTLA-4 by ipilimumab could augment...
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| Główni autorzy: | , , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2010
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2992836/ https://ncbi.nlm.nih.gov/pubmed/20713164 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbmt.2010.08.005 |
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