High Glucose Increases Lysyl Oxidase Expression and Activity in Retinal Endothelial Cells: Mechanism for Compromised Extracellular Matrix Barrier Function

OBJECTIVE: In diabetes, retinal vascular basement membrane (BM) undergoes significant thickening and compromises vessel function including increased vascular permeability, a prominent lesion of early diabetic retinopathy. In this study we determined whether altered expression and activity of lysyl o...

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Главные авторы: Chronopoulos, Argyrios, Tang, Amanda, Beglova, Ekaterina, Trackman, Philip C., Roy, Sayon
Формат: Artigo
Язык:Inglês
Опубликовано: American Diabetes Association 2010
Предметы:
Pathophysiology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992778/
https://ncbi.nlm.nih.gov/pubmed/20823103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-0365
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