Deletion of Pten in Pancreatic β-Cells Protects Against Deficient β-Cell Mass and Function in Mouse Models of Type 2 Diabetes

OBJECTIVE: Type 2 diabetes is characterized by diminished pancreatic β-cell mass and function. Insulin signaling within the β-cells has been shown to play a critical role in maintaining the essential function of the β-cells. Under basal conditions, enhanced insulin-PI3K signaling via deletion of pho...

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Main Authors: Wang, Linyuan, Liu, Yunfeng, Yan Lu, Shun, Nguyen, Kinh-Tung T., Schroer, Stephanie A., Suzuki, Akira, Mak, Tak W., Gaisano, Herbert, Woo, Minna
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2010
Assuntos:
Islet Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992773/
https://ncbi.nlm.nih.gov/pubmed/20852026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-1805
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