Detection of copy number variation from array intensity and sequencing read depth using a stepwise Bayesian model

BACKGROUND: Copy number variants (CNVs) have been demonstrated to occur at a high frequency and are now widely believed to make a significant contribution to the phenotypic variation in human populations. Array-based comparative genomic hybridization (array-CGH) and newly developed read-depth approa...

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Bibliographic Details
Main Authors: Zhang, Zhengdong D, Gerstein, Mark B
Format: Artigo
Language:Inglês
Published: BioMed Central 2010
Subjects:
Methodology Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992546/
https://ncbi.nlm.nih.gov/pubmed/21034510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-11-539
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