NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegeneration

BACKGROUND: The phosphatase PTEN governs the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway which is arguably the most important pro-survival pathway in neurons. Recently, PTEN has also been implicated in multiple important CNS functions such as neuronal differentiation, plasticity, injury a...

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Hlavní autoři: Kwak, Young-Don, Ma, Tao, Diao, Shiyong, Zhang, Xue, Chen, Yaomin, Hsu, Janet, Lipton, Stuart A, Masliah, Eliezer, Xu, Huaxi, Liao, Francesca-Fang
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2010
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992530/
https://ncbi.nlm.nih.gov/pubmed/21067594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-5-49
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