Oridonin induces apoptosis and senescence in colorectal cancer cells by increasing histone hyperacetylation and regulation of p16, p21, p27 and c-myc

BACKGROUND: Oridonin, a tetracycline diterpenoid compound, has the potential antitumor activities. Here, we evaluate the antitumor activity and action mechanisms of oridonin in colorectal cancer. METHODS: Effects of oridonin on cell proliferation were determined by using a CCK-8 Kit. Cell cycle dist...

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Autors principals: Gao, Feng-Hou, Hu, Xiao-Hui, Li, Wei, Liu, Hua, Zhang, Yan-Jie, Guo, Zhu-Ying, Xu, Mang-Hua, Wang, Shi-Ting, Jiang, Bin, Liu, Feng, Zhao, Ying-Zheng, Fang, Yong, Chen, Fang-Yuan, Wu, Ying-Li
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2010
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992521/
https://ncbi.nlm.nih.gov/pubmed/21054888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-10-610
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