Behavioral deficits and progressive neuropathology in progranulin-deficient mice: a mouse model of frontotemporal dementia

Progranulin haploinsufficiency causes frontotemporal dementia with tau-negative, ubiquitin-positive neuronal inclusion pathology. In this study, we showed that progranulin-deficient mice displayed increased depression- and disinhibition-like behavior, as well as deficits in social recognition from a...

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Hauptverfasser: Yin, Fangfang, Dumont, Magali, Banerjee, Rebecca, Ma, Yao, Li, Huihong, Lin, Michael T., Beal, M. Flint, Nathan, Carl, Thomas, Bobby, Ding, Aihao
Format: Artigo
Sprache:Inglês
Veröffentlicht: Federation of American Societies for Experimental Biology 2010
Schlagworte:
Research Communications
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992364/
https://ncbi.nlm.nih.gov/pubmed/20667979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.10-161471
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