Flexibility of the Thrombin-activatable Fibrinolysis Inhibitor Pro-domain Enables Productive Binding of Protein Substrates

We have previously reported that thrombin-activatable fibrinolysis inhibitor (TAFI) exhibits intrinsic proteolytic activity toward large peptides. The structural basis for this observation was clarified by the crystal structures of human and bovine TAFI. These structures evinced a significant rotati...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Valnickova, Zuzana, Sanglas, Laura, Arolas, Joan L., Petersen, Steen V., Schar, Christine, Otzen, Daniel, Aviles, Francesc X., Gomis-Rüth, F. Xavier, Enghild, Jan J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2010
Gaiak:
Protein Structure and Folding
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992258/
https://ncbi.nlm.nih.gov/pubmed/20880845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.150342
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