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Parkin Mono-ubiquitinates Bcl-2 and Regulates Autophagy
Parkin is an E3 ubiquitin ligase that mediates the ubiquitination of protein substrates. The mutations in the parkin gene can lead to a loss of function of parkin and cause autosomal recessive juvenile onset parkinsonism. Recently, parkin was reported to be involved in the regulation of mitophagy. H...
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| Autores principales: | , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2010
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2992255/ https://ncbi.nlm.nih.gov/pubmed/20889974 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.101469 |
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