Structures of the Human GTPase MMAA and Vitamin B(12)-dependent Methylmalonyl-CoA Mutase and Insight into Their Complex Formation

Vitamin B(12) (cobalamin, Cbl) is essential to the function of two human enzymes, methionine synthase (MS) and methylmalonyl-CoA mutase (MUT). The conversion of dietary Cbl to its cofactor forms, methyl-Cbl (MeCbl) for MS and adenosyl-Cbl (AdoCbl) for MUT, located in the cytosol and mitochondria, re...

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Main Authors: Froese, D. Sean, Kochan, Grazyna, Muniz, João R. C., Wu, Xuchu, Gileadi, Carina, Ugochukwu, Emelie, Krysztofinska, Ewelina, Gravel, Roy A., Oppermann, Udo, Yue, Wyatt W.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2010
נושאים:
Metabolism
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992254/
https://ncbi.nlm.nih.gov/pubmed/20876572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.177717
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