Mutational Analysis of Saccharomyces cerevisiae Erf2 Reveals a Two-step Reaction Mechanism for Protein Palmitoylation by DHHC Enzymes

DHHC protein acyltransferases (PATs) catalyze the palmitoylation of eukaryotic proteins through an enzymatic mechanism that remains largely unexplored. In this study we have combined genetic and biochemical approaches to examine the molecular mechanism of palmitate transfer of the yeast Ras PAT, whi...

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Detalles Bibliográficos
Autores principales: Mitchell, David A., Mitchell, Gayatri, Ling, Yiping, Budde, Cheryl, Deschenes, Robert J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Lipids
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992244/
https://ncbi.nlm.nih.gov/pubmed/20851885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.169102
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