Mutational Analysis of Saccharomyces cerevisiae Erf2 Reveals a Two-step Reaction Mechanism for Protein Palmitoylation by DHHC Enzymes

DHHC protein acyltransferases (PATs) catalyze the palmitoylation of eukaryotic proteins through an enzymatic mechanism that remains largely unexplored. In this study we have combined genetic and biochemical approaches to examine the molecular mechanism of palmitate transfer of the yeast Ras PAT, whi...

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Main Authors: Mitchell, David A., Mitchell, Gayatri, Ling, Yiping, Budde, Cheryl, Deschenes, Robert J.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2010
Teme:
Lipids
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992244/
https://ncbi.nlm.nih.gov/pubmed/20851885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.169102
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