Heat Shock Protein 90 as a Drug Target against Protozoan Infections: BIOCHEMICAL CHARACTERIZATION OF HSP90 FROM PLASMODIUM FALCIPARUM AND TRYPANOSOMA EVANSI AND EVALUATION OF ITS INHIBITOR AS A CANDIDATE DRUG

Using a pharmacological inhibitor of Hsp90 in cultured malarial parasite, we have previously implicated Plasmodium falciparum Hsp90 (PfHsp90) as a drug target against malaria. In this study, we have biochemically characterized PfHsp90 in terms of its ATPase activity and interaction with its inhibito...

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Main Authors: Pallavi, Rani, Roy, Nainita, Nageshan, Rishi Kumar, Talukdar, Pinaki, Pavithra, Soundara Raghavan, Reddy, Raghunath, Venketesh, S., Kumar, Rajender, Gupta, Ashok Kumar, Singh, Raj Kumar, Yadav, Suresh Chandra, Tatu, Utpal
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Molecular Bases of Disease
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992230/
https://ncbi.nlm.nih.gov/pubmed/20837488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.155317
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