Construction and expression of a recombinant antibody-targeted plasminogen activator.

Covalent linkage of tissue-type plasminogen activator (t-PA) to a monoclonal antibody specific for the fibrin beta chain (anti-fibrin 59D8) results in a thrombolytic agent that is more specific and more potent than t-PA alone. To provide a ready source of this hybrid molecule and to allow tailoring...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Schnee, J M, Runge, M S, Matsueda, G R, Hudson, N W, Seidman, J G, Haber, E, Quertermous, T
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1987
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC299193/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3116546/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.19.6904
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