Construction and expression of a recombinant antibody-targeted plasminogen activator.
Covalent linkage of tissue-type plasminogen activator (t-PA) to a monoclonal antibody specific for the fibrin beta chain (anti-fibrin 59D8) results in a thrombolytic agent that is more specific and more potent than t-PA alone. To provide a ready source of this hybrid molecule and to allow tailoring...
Збережено в:
| Опубліковано в:: | Proc Natl Acad Sci U S A |
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| Автори: | , , , , , , |
| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
National Academy of Sciences
1987
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| Предмети: | |
| Онлайн доступ: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC299193/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3116546/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.19.6904 |
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