A cis-acting element is necessary and sufficient for translational regulation of human ferritin expression in response to iron.

Ferritin plays a key role in determining the intracellular fate of iron and is highly regulated by the iron status of the cell. We have identified a cis-acting element in the transcribed but nontranslated 5' leader sequence of human ferritin heavy-chain mRNA. In transiently transfected murine fibrob...

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Udgivet i:	Proc Natl Acad Sci U S A
Principais autores:	Hentze, M W, Rouault, T A, Caughman, S W, Dancis, A, Harford, J B, Klausner, R D
Format:	Artigo
Sprog:	Inglês
Udgivet:	National Academy of Sciences 1987
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC299157/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3477805/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.19.6730
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