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Redox Regulation of Guanylate Cyclase and Protein Kinase G in Vascular Responses to Hypoxia

The production of cGMP by the soluble form of guanylate cyclase (sGC) in bovine pulmonary arteries (BPA) is controlled by cytosolic NADPH maintaining reduced thiol and heme sites on sGC needed for activation by NO, and the levels of Nox oxidase-derived superoxide and peroxide that influence pathways...

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Bibliografiske detaljer
Main Authors: Neo, Boon Hwa, Kandhi, Sharath, Ahmad, Mansoor, Wolin, Michael S
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2991487/
https://ncbi.nlm.nih.gov/pubmed/20831906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.resp.2010.08.024
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