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Primary pneumonic plague in the African Green monkey as a model for treatment efficacy evaluation
BACKGROUND: Primary pneumonic plague is rare among humans but treatment efficacy may be tested in appropriate animal models under the FDA ‘Animal Rule’. METHODS: Ten African Green monkeys (AGM) inhaled 44 to 255 LD(50) doses of aerosolized Y. pestis strain CO92. Continuous telemetry, arterial blood...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2991483/ https://ncbi.nlm.nih.gov/pubmed/20722770 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-0684.2010.00443.x |
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