Primary pneumonic plague in the African Green monkey as a model for treatment efficacy evaluation

BACKGROUND: Primary pneumonic plague is rare among humans but treatment efficacy may be tested in appropriate animal models under the FDA ‘Animal Rule’. METHODS: Ten African Green monkeys (AGM) inhaled 44 to 255 LD(50) doses of aerosolized Y. pestis strain CO92. Continuous telemetry, arterial blood...

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Hlavní autoři: Layton, R. Colby, Brasel, Trevor, Gigliotti, Andrew, Barr, Edward, Storch, Steven, Myers, Leslie, Hobbs, Charles, Koster, Frederick
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2991483/
https://ncbi.nlm.nih.gov/pubmed/20722770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-0684.2010.00443.x
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